| Fiscal period | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|
| Period End Date | 12/31/2025 | 12/31/2024 | 12/31/2023 | 12/31/2022 | 12/31/2021 | 12/31/2020 | 12/31/2019 | 12/31/2018 | 12/31/2017 | 12/31/2016 |
|---|
| Service sales | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| License fees | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net product sales | 3,182.70 | 2,877.40 | 2,327.50 | 1,936.30 | 1,685.50 | 1,483.30 | 1,448.80 | 1,627.80 | 1,725.30 | 1,598.80 |
| Service sales to affiliates | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other revenues | -- | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- |
| Grant revenue | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Total Revenues | 3,182.70 | 2,877.40 | 2,327.50 | 1,936.30 | 1,685.50 | 1,483.30 | 1,448.80 | 1,627.80 | 1,725.30 | 1,598.80 |
| Cost of product sales | 384.40 | 309.70 | 257.50 | 151.60 | 122.50 | 108.10 | 117.60 | 198.70 | 105.70 | 72.70 |
| Cost of service sales | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Research and development | 550.00 | 481.00 | 408.00 | 322.90 | 540.10 | 357.70 | 1,182.60 | 357.90 | 264.60 | 147.60 |
| Selling, general and administrative | 755.80 | 709.70 | 477.10 | 482.10 | 467.00 | 423.90 | 336.20 | 265.80 | 330.10 | 316.80 |
| Sales and marketing | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Impairment of HeartBar® trade name | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Settlement of loss contingency | -- | -- | -- | -- | -- | -- | 0.00 | 0.00 | (210.00) | -- |
| Total Operating Expenses | 1,690.20 | 1,500.40 | 1,142.60 | 956.60 | 1,129.60 | 889.70 | 1,636.40 | -- | 910.40 | 537.10 |
| Operating Income (Loss) | 1,492.50 | 1,377.00 | 1,184.90 | 979.70 | 555.90 | 593.60 | (187.60) | 805.40 | 814.90 | 1,061.70 |
| Interest expense | 19.50 | 42.90 | 59.30 | 32.40 | 18.60 | 23.50 | 44.20 | 13.90 | 9.00 | 3.90 |
| Write-down of investment | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Impairment of cost method investment | -- | -- | -- | -- | -- | -- | 0.00 | 53.50 | 49.60 | -- |
| Impairments of investments in privately-held companies | -- | 0.00 | 0.00 | 1.70 | 2.30 | 9.10 | -- | -- | -- | -- |
| Gain on sale of intangible asset | -- | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- |
| Gain (Loss) on marketable investments | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Equity loss in affiliate | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Interest income | 192.00 | 199.10 | 162.70 | 45.20 | 16.70 | 28.60 | 44.20 | 28.60 | -- | -- |
| Other income (expense) | 48.90 | 5.80 | (14.00) | (40.20) | 42.20 | 49.30 | 22.60 | (7.70) | 13.20 | 2.40 |
| Total other (expense) income, net | 221.40 | 162.00 | 89.40 | (29.10) | 38.00 | 45.30 | 22.60 | 822.40 | (45.40) | (1.50) |
| Income before income tax | 1,713.90 | 1,539.00 | 1,274.30 | 950.60 | 593.90 | 638.90 | (165.00) | 758.90 | 769.50 | 1,060.20 |
| Current- Foreign | 1.20 | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Current: Federal | -- | -- | -- | -- | -- | -- | -- | -- | 261.30 | 311.90 |
| Current: State | -- | -- | -- | -- | -- | -- | -- | -- | 23.90 | 24.10 |
| Deferred: Federal | -- | -- | -- | -- | -- | -- | -- | -- | 67.20 | 8.30 |
| Deferred: State | -- | -- | -- | -- | -- | -- | -- | -- | (0.80) | 2.20 |
| Deferred: Foreign | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Income tax provision (benefit) | 379.20 | 343.90 | 289.50 | 223.30 | 118.10 | 124.10 | (60.50) | 169.70 | 351.60 | 346.50 |
| Other Non-Current: Federal | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Non-Current: State | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other non-current: Foreign | (0.50) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Income from Continuing Operations | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Income from Discontinued Operations | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Gain on disposal of discontinued operations, net of tax | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net Income (loss) Available to Common Shareholders | 1,334.70 | 1,195.10 | 984.80 | 727.30 | 475.80 | 514.80 | (104.50) | 589.20 | 417.90 | 713.70 |
| Income from continuing operations -EPS (Basic) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Discontinued operations EPS (Basic) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net Earnings Per Share (Basic) | 30.13 | 26.44 | 21.04 | 15.98 | 10.60 | 11.65 | (2.39) | 13.54 | 9.50 | 16.29 |
| Income from continuing operations -EPS (Diluted | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Discontinued operations EPS (Diluted) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net Earnings Per Share (Diluted) | 27.86 | 24.64 | 19.81 | 15.00 | 10.06 | 11.54 | (2.39) | 13.39 | 9.31 | 15.25 |
| Weighted Average Shares Outstanding (Basic) | 44.30 | 45.20 | 46.80 | 45.50 | 44.90 | 44.20 | 43.80 | 43.50 | 44.00 | 43.80 |
| Weighted Average Shares Outstanding (Diluted) | 47.90 | 48.50 | 49.70 | 48.50 | 47.30 | 44.60 | 43.80 | 44.00 | 44.90 | 46.80 |