| Fiscal period | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 |
|---|
| Period End Date | 12/31/2021 | 12/31/2020 | 12/31/2019 | 12/31/2018 | 12/31/2017 | 12/31/2016 | 12/31/2015 | 12/31/2014 | 12/31/2013 | 12/31/2012 |
|---|
| Service sales | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| License fees | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net product sales | 1,685.50 | 1,483.30 | 1,448.80 | 1,627.80 | 1,725.30 | 1,598.80 | 1,460.60 | 1,279.50 | 1,106.94 | 906.12 |
| Service sales to affiliates | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other revenues | -- | -- | -- | -- | -- | -- | 5.20 | 9.00 | 10.04 | 9.95 |
| Grant revenue | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Total Revenues | 1,685.50 | 1,483.30 | 1,448.80 | 1,627.80 | 1,725.30 | 1,598.80 | 1,465.80 | 1,288.50 | 1,116.98 | 916.08 |
| Cost of product sales | 122.50 | 108.10 | 117.60 | 198.70 | 105.70 | 72.70 | 69.00 | 125.90 | 131.13 | 119.30 |
| Cost of service sales | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Research and development | 540.10 | 357.70 | 1,182.60 | 357.90 | 264.60 | 147.60 | 245.10 | 242.50 | 299.35 | 173.39 |
| Selling, general and administrative | 467.00 | 423.90 | 336.20 | 265.80 | 330.10 | 316.80 | 452.70 | 381.30 | 394.01 | 201.75 |
| Sales and marketing | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Settlement of loss contingency | -- | -- | -- | -- | (210.00) | 0.00 | -- | -- | -- | -- |
| Total Operating Expenses | 1,129.60 | 889.70 | 1,636.40 | 822.40 | 910.40 | -- | 766.80 | 749.70 | -- | 494.43 |
| Operating Income (Loss) | 555.90 | 593.60 | (187.60) | 805.40 | 814.90 | 1,061.70 | 699.00 | 538.80 | 292.50 | 421.65 |
| Interest expense | 18.60 | 23.50 | 44.20 | 13.90 | 9.00 | 3.90 | 4.70 | 17.60 | 18.06 | 16.64 |
| Write-down of investment | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Impairment of cost method investment | -- | -- | -- | -- | 49.60 | 0.00 | 0.00 | -- | -- | -- |
| Impairments of investments in privately-held companies | 2.30 | 9.10 | 0.00 | 53.50 | -- | -- | -- | -- | -- | -- |
| Gain on sale of intangible asset | -- | -- | -- | -- | -- | -- | 350.00 | -- | 0.00 | -- |
| Gain (Loss) on marketable investments | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Equity loss in affiliate | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Interest income | 16.70 | 28.60 | 44.20 | 28.60 | 10.90 | 3.50 | -- | -- | -- | -- |
| Other income (expense) | 42.20 | 49.30 | 22.60 | (7.70) | 2.30 | (1.10) | 0.10 | 4.00 | 4.46 | 35.66 |
| Total other (expense) income, net | 38.00 | 45.30 | 22.60 | (46.50) | (45.40) | 537.10 | 345.40 | (13.60) | 824.49 | 19.03 |
| Income before income tax | 593.90 | 638.90 | (165.00) | 758.90 | 769.50 | 1,060.20 | 1,044.40 | 525.20 | 278.90 | 440.67 |
| Current- Foreign | -- | -- | -- | -- | -- | -- | -- | -- | 2.16 | 0.66 |
| Current: Federal | -- | -- | -- | -- | -- | -- | 351.20 | 166.40 | 120.03 | 83.91 |
| Current: State | -- | -- | -- | -- | -- | -- | 37.00 | 21.40 | 20.10 | 13.95 |
| Deferred: Federal | -- | -- | -- | -- | -- | -- | (2.70) | (3.10) | (37.71) | 37.26 |
| Deferred: State | -- | -- | -- | -- | -- | -- | 7.30 | 0.40 | (9.06) | (0.42) |
| Deferred: Foreign | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Income tax provision (benefit) | 118.10 | 124.10 | (60.50) | 169.70 | 351.60 | 346.50 | 392.80 | 185.10 | 104.34 | 136.23 |
| Other Non-Current: Federal | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Non-Current: State | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other non-current: Foreign | -- | -- | -- | -- | -- | -- | -- | -- | (1.06) | 0.18 |
| Income from Continuing Operations | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Income from Discontinued Operations | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Gain on disposal of discontinued operations, net of tax | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net Income (loss) Available to Common Shareholders | 475.80 | 514.80 | (104.50) | 589.20 | 417.90 | 713.70 | 651.60 | 340.10 | 174.56 | 304.44 |
| Income from continuing operations -EPS (Basic) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Discontinued operations EPS (Basic) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net Earnings Per Share (Basic) | 10.60 | 11.65 | (2.39) | 13.54 | 9.50 | 16.29 | 14.17 | 7.06 | 3.49 | 5.84 |
| Income from continuing operations -EPS (Diluted | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Discontinued operations EPS (Diluted) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Net Earnings Per Share (Diluted) | 10.06 | 11.54 | (2.39) | 13.39 | 9.31 | 15.25 | 12.72 | 6.28 | 3.28 | 5.71 |
| Weighted Average Shares Outstanding (Basic) | 44.90 | 44.20 | 43.80 | 43.50 | 44.00 | 43.80 | 46.00 | 48.20 | 50.08 | 52.09 |
| Weighted Average Shares Outstanding (Diluted) | 47.30 | 44.60 | 43.80 | 44.00 | 44.90 | 46.80 | 51.20 | 54.20 | 53.23 | 53.28 |